英语翻译Asporin (ASPN)Asporin,a small leucine-rich repeat protei

英语翻译
Asporin (ASPN)
Asporin,a small leucine-rich repeat protein,encodes
an extracellular matrix protein that binds other
structural components of the extracellular matrix,including
collagen and TGF_.
Mice deficient in small
leucine-rich proteins,such as fibromodulin,or in biglycan
and fibromodulin,develop a mild and a severe
premature OA,respectively (38,39).Asporin mRNA is
also expressed abundantly in OA cartilage (37).Epidemiologic
studies in a Japanese population (40) have
shown that a specific aspartic acid repeat polymorphism
in ASPN is associated with inhibition of chondrogenesis
and increased susceptibility to OA (Table 3).In this
study,the D14 allele (referring to a unique repeat region
in the N-terminal region) was significantly more frequent
in patients with knee OA than control subjects,
while the D13 allele was significantly less common in
patients than in control subjects,suggesting a protective
effect.

Asporin (ASPN) 无孢蛋白
Asporin,a small leucine-rich repeat protein,encodes an extracellular matrix protein that binds other structural components of the extracellular matrix,including collagen and TGF_.
无孢蛋白是一种富含亮氨酸的重复序列小分子蛋白,包含细胞外基质蛋白结合其他的结构成分,包括胶原和转化生长因子.
Mice deficient in small leucine-rich proteins,such as fibromodulin,or in biglycan and fibromodulin,develop a mild and a severe premature OA,respectively (38,39).Asporin mRNA is also expressed abundantly in OA cartilage (37).
缺乏富含亮氨酸小分子蛋白如纤维调节素的小鼠,会产生轻微的过早骨关节炎(38),如果是缺乏二聚糖及纤维调节素,炎症则会比较严重（39）.关节软骨中也显示大量的无孢蛋白基因（37）.
Epidemiologic studies in a Japanese population (40) have shown that a specific aspartic acid repeat polymorphism in ASPN is associated with inhibition of chondrogenesis and increased susceptibility to OA (Table 3).
针对日本人群的流行病学研究（40）显示,在无孢蛋白中的一种特殊天冬氨酸重复多态性是与软骨形成的抑制性有关联,并能增加对骨性关节炎的感染（表格3）.
In this study,the D14 allele (referring to a unique repeat region in the N-terminal region) was significantly more frequent in patients with knee OA than control subjects,while the D13 allele was significantly less common in patients than in control subjects,suggesting a protective effect.
在本研究中,D14等位基因（指在N-氨基末端区域的一个独特区）出现在膝盖关节炎病患中明显地比正常对照组较为频密,而D13等位基因则在病患中比正常对照组较少出现,表示有保护性作用.
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