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have trouble in,have trouble with 有什么区别?

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have trouble in,have trouble with 有什么区别?
He has trouble____ grammer.A.with B .in C.of
1.have trouble in 有困难, 费事
I have some trouble (in) reading the letter. His handwriting is very bad.
我读这封信很费劲, 他的字很差.
2.have trouble with 有病痛, 因…苦恼
She is having trouble with her teeth.
她牙齿痛.
同…闹纠纷
We had trouble with our neighbors over the noise that they were making.
我们因邻居制造的噪音而与他们闹纠纷.
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不明白的再问哟,请及时采纳,多谢