作业帮基因组学里的variant calling是什么意思?
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基因组学里的variant calling是什么意思?
您好,calling在这里是识别的意思,除了variant calling（识别变体）,还有genotype calling（识别基因型）、base calling（识别碱基）等.可以参考以下文献的中英版本：
Mapping short DNA sequencing reads and calling variants using mapping quality scores
Genome Res H. Li J. Ruan R. Durbin
...Error probabilities are also derived for the final genotype calls, using a Bayesian statistical model that incorporates the mapping qualities, error probabilities from the raw sequence quality scores, sampling of the two haplotypes, and an empirical model for correlated errors at a site. Both read mapping and genotype calling（
Mapping short DNA sequencing reads and calling variants using mapping quality scores
Genome Res H. Li J. Ruan R. Durbin
...Error probabilities are also derived for the final genotype calls, using a Bayesian statistical model that incorporates the mapping qualities, error probabilities from the raw sequence quality scores, sampling of the two haplotypes, and an empirical model for correlated errors at a site. Both read mapping and genotype calling（