He ran into the classroom,___a letter in his hand.(拿着）

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with
再问： holding可以吗？
再答：不行，这个是with的一种特殊用法 ~~~~~~~~~~~~~~~~~~~祝你进步，有疑问可追问，请及时采纳~~~~~~~~~~~~~~~~~~
再问：二者有什么不同
再答：这是一个固定用法 with+名词或代词+介词短语”结构，做状语，表示状态意思是手里拿着一封信　 holding 主语应该是人，而后面又出现了　in his hand,　在他手里，手拿着信　在他手里　意思是重复的．

He ran into the classroom,___a letter in his hand.(拿着） He ran into the classroom,___a book in his hand.(拿着） He runs into his room,__ (拿着) a letter in his hand . （）two books（）his hand ,he ran（）（）the classroom and diaappear He came into the classroom _____ a book in his hand. [& He came into the classroom with a book in his The teacher came into the classroom __ a book in his hand如题 The teachercame into the classroom _____a book in his hand介词 Mr Li comes into the classroom and a book in his hand. Ted came into the classroom _____a book in his hand.A.with B He ran into the classroom as fast as possible(改为同义句） He ran into the car in front of him on his way home because