英语翻译Whereas Clp1K/K neonates on the CBA/J background had app

英语翻译
Whereas Clp1K/K neonates on the CBA/J background had apparently normal numbers of spinal motor neurons,4-month-old Clp1K/K mice showed both a marked reduction in ChAT1 and,as a second marker,SMI-321 spinal motor neurons .The effects of the Clp1 mutation on upper motor neurons need to be assessed.Consistent with lower motor neuron loss,we observed axonopathy of peripheral nerves such as the sciatic nerve.Immunostaining showed amyloid-b precursor protein (APP)-positive structures,a marker for axonal injury14,in the sciatic nerves of adult Clp1K/K mice.In line with motor-neuron loss,we observed a marked reduction in the number of large diameter fibres,whereas the smaller sensory fibres were largely preserved.Dorsal root ganglion (DRG) sensory neurons showed normal morphology and outgrowth.Whether developmental alterations in myelination also contribute to the phenotype needs to be further assessed.We also observed regional denervation and fragmentation of NMJs in the diaphragm,and in various limb and head skeletal muscles,resulting in skeletal muscle atrophy; slow-twitch muscles (soleus,gluteus) were less affected than the fast-twitch extensor digitorum longus or gastrocnemius muscles.Similar results were obtained in SOD1 transgenic mice15.Thus,Clp1K/K mice develop progressive loss of spinal motor neurons and exhibit defective NMJs,resulting in impaired motor functions,muscular atrophy and limb paralysis.
用翻译软件翻的那种根本不能用，也别指望我采纳，软件能用我早就自己翻了

CBA/J背景而Clp1K/ K新生儿的脊髓运动神经元,显然是正常的数字的4月龄Clp1K/ K的小鼠表现出明显减少客服1,第二个标记,SMI-321脊髓运动神经元.的CLP1突变的上上运动神经元的影响需要进行评估.下运动神经元损失相一致,我们观察到如坐骨神经周围神经轴突.免疫染色显示-B淀粉样蛋白前体蛋白（APP）的阳性结构一个标记轴突injury14的,在成人Clp1K/K小鼠坐骨神经.线与运动神经元损失,我们观察到的大直径纤维的数量显着减少,而更小的感觉纤维在很大程度上保留.背根神经节（DRG）感觉神经元形态正常产物.髓鞘的发育改变是否也有助于表型需要进一步评估.我们还观察到区域神经性隔膜NMJs碎片,和各种肢体和头部骨骼肌肉,导致骨骼肌萎缩;慢肌肌肉（比目鱼肌,臀肌）的影响比快肌趾长伸肌或腓肠肌肌肉.SOD1基因mice15获得了类似的结果.因此,开发逐渐丧失Clp1K/K小鼠的脊髓运动神经元,并表现出缺陷NMJs,导致运动功能受损,肌肉萎缩,肢体瘫痪.