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You can never imagine what great trouble I have had ______ t

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You can never imagine what great trouble I have had ______ the patient who received a serious wound.
A.treat B.to treat C.treating D.treated
Little Tommy was reluctant to tell the headmaster _______ he had done the day before.
A.that B.how C.where D.what
C
D
第一题还原一下就是I have had great trouble [in] treating the patient
第二题是宾语从句 从句中缺少宾语用WHAT