by the time she got to class,the teacher had already started

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by the time she got to class,the teacher had already started teaching
中的by the time可以用下面那个词代换
A.when B.as soon as C.since D.while

when啊
可以互换的.
当她到教室的时候,老师早已开始教学.
B项一……就……通常出现在时间状语从句中吧
而since是引导一个完整的陈述句或者时间点自从..
while后用过去进行时当..的时候和when有区别但不大
when后接一般过去时

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